Since their introduction more than three decades ago, mechanical needle guides have been used to assist clinicians in the accuracy of placing needles for a variety of procedures such as biopsies, ablations, peripheral nerve blocks, vascular access, joint injections, and numerous others. But can a needle guide simplify the procedure? Can they reduce procedure times? Can they improve clinical confidence? Finally, and perhaps most importantly, can they improve patient safety? These are some important questions, so let’s look at each one of them individually.